Insulomin-R 60 tablets YAMAMOTO

What is Insulomin-R® and what is it used for?

Yamamoto® Nutrition Insulomin-R is a dietary supplement developed to supportcarbohydrate metabolism, improveinsulin sensitivity, andmaintainstable blood glucose levels. Made entirely from plant extracts (barberry, bitter melon, gymnema, cinnamon) and enriched with chromium and R-alpha-lipoic acid, Insulomin-R is an innovative, comprehensive, and effectiveGDA(Glucose Disposal Agent) that helps the bodyabsorb carbohydrates more efficientlyanddirectthem toward the formation of muscle and liver glycogen.

It is well known that diets high in carbohydrates, when followed over an extended period, can contribute toa decrease in insulin sensitivity, leading tosystemic inflammationanda tendencyto accumulate body fat.

Consistently high insulin levels (hyperinsulinemia) can impair the body’s ability to utilize carbohydrates and also affect how muscle cells metabolize them, resulting in an excess of unused circulating glucose, which is then converted into triglycerides through a process known as“de novo lipogenesis.” The triglycerides produced will then be stored in adipose tissue, fueling an altered metabolic state that is clearly at odds with both athletic and general health goals.

In fact, all athletes need to maintain propernutrient partitioning—that is, anefficient distribution of macronutrients: ensuring good insulin sensitivity through training, nutrition, and supplementation is essential for improving how muscle cells manage carbohydrates, promoting their use for glycogen production and thereby optimizing bothperformanceandrecovery.

The role of GDAs is, in fact, to ensure that the insulin released by the pancreas following the consumption of a carbohydrate-rich meal directs carbohydrates toward muscle cells, thereby enhancing the muscle-building process. Using a GDA supplement does not replace the need to first adjust your diet, which should be varied and balanced, but Insulomin-R can helpsupport metabolic health by re-sensitizing cells to insulin’s action and significantly restoring proper carbohydrate absorption. This effect is clearly beneficial not only for athletes and sports enthusiasts but also in cases of insulin resistance.

What are the ingredients in Insulomin-R®?

The active ingredients in Insulomin-R arealpha-lipoic acid, barberry extract (berberine),bitter melon extract(Momordicin®), and Gymnema Sylvestre,cinnamon, andchromium picolinate. This synergy of active ingredients helps enhance the body’s natural insulin response, promoting a greater flow of glucose to muscle cells and reducing the likelihood that this sugar will be converted and stored in adipose tissue.

Alpha-lipoic acidisa fat-soluble molecule found in abundance in mitochondria, and its use is recommended for the treatmentof hyperglycemiaaswellasfor women suffering frompolycystic ovary syndrome(PCOS). It is proposed as a NON-pharmacological solution for prediabetes to normalize blood glucose levels, and there are numerous scientific studies supporting its efficacy, clearly demonstrating the benefits of taking it.

Berberine, derived from barberry extract, is a potent alkaloid recommended for those suffering frominsulin resistanceandforblood sugar management. It works by activating AMPK (Adenosine Monophosphate-activated Protein Kinase), a key enzyme in cellular energy metabolism. The main effects of AMPK activation includestimulating hepatic fatty acid oxidation,ketogenesis, slowinglipogenesis(fat formation), and inhibiting the synthesis of cholesterol and triglycerides. This enzyme also has the ability to stimulate glucose uptake by muscle and modulate insulin secretion by pancreatic beta cells. Using Berberine therefore allows for better utilization of carbohydrates by muscle cells, supporting glycogen synthesis and recovery.

Bitter melon(also knownasMomordica charantia) appears to have apowerful insulin-sensitizing effect, making it useful for improving insulin resistance (caused by high sugar intake over an extended period, bulking phases, or prolonged hyperglycemia). Modern scientific evidence agrees that bitter melon is one of themost promising plants for the natural treatment of diabetes: it can stimulate insulin secretion (through complex mechanisms of action that include the activation of AMPK and the inhibition of PTP1B, which typically deactivates the insulin receptor), and increase the expression of the GLUT-4 glucose transporter.

The extract of the climbing plant Gymnema Sylvestre is of interest for its role in weight management: its leaves are rich in polyphenols and triterpenic glycosides (such asgurmarinandgymnemic acid A1), substances that act by binding to taste receptors on the tongue (gurmarin), thereby reducing the perception of sweetnessandconsequently lowering the craving for sugar-based foods, as well as to glucose receptors in the intestinal tract (gymnemic acid A1), reducing sugar absorption. On average, the blocking of glucose receptors occurs about an hour after taking gymnema and lasts for several hours: scientific literature even suggests a parallel regeneration of the pancreas’s endocrine cells. Consequently, the body’s cells will, on the one hand, absorb less glucose and, on the other, be able to easily convert ingested sugars intofuelforthe body.

Cinnamoniswell known not only as a spice but also for its ability tokeep blood sugar levels low: it can inhibit various pancreatic enzymes that break down starch, malt, and sucrose (such as alpha-amylase, maltase, and intestinal sucrase). This prevents the sugars and starches consumed with a meal from being digested, slowing the absorption of glucose into the bloodstream.

Chromiumhelpsmaintain normal blood glucose levels and supports the proper metabolism of macronutrients; its picolinate form is absorbed more easily than other forms, supporting the goal of Insulomin-R:to improve the transportandutilization of the carbohydrates we consume, whether duringmuscle-buildingorweight-loss phases.

• AR = Reference assumptions