GLR Setria® Sublingual 30 orodispersible chewable tablets YAMAMOTO

Yamamoto® Research GLR® Setria® Sublingual is a food supplement in rapidly dissolving sublingual tablets that provides 250 mg per daily dose of Reduced L-Glutathione (Setria®) together with Vitamin C and Selenium. Glutathione is a powerful antioxidant molecule that plays a key role in the defense of the body from oxidative stress and from the action of free radicals and which is capable of protect hepatocytes from toxic molecules which could cause liver damage. The formulation in fast-dissolving sublingual tablets It allows the body to rapidly and optimally absorb glutathione from the sublingual venous circulation, tributary to the superior vena cava, bypassing the intestinal activity of gamma-glutamyltransferases and avoiding enterocyte metabolic avidity. This bypasses the "hepatic filter" and avoids the first-pass metabolism that normally occurs in the liver, which deactivates a large portion of the glutathione molecule, making it less functional and effective.

Glutathione is one of our first lines of defense, a ubiquitous molecule, meaning it is present throughout our organism, but it is It is particularly concentrated in the liver , where it protects liver cells from toxic molecules. In this case, glutathione "binds" to toxic metabolites, neutralizing them. Reduced glutathione is able to release its hydrogen (H+), which acts as an electron acceptor (e-) from reactive oxygen species, or free radicals. At this point, having eliminated the danger caused by free radicals, glutathione can regain its antioxidant activity and return to its reduced form. Glutathione's ability to continuously regenerate itself is the reason why this molecule is considered the most powerful antioxidant in the human body. The biological functions of glutathione support its clinical utility in several situations, first and foremost its ability to protect the liver from the action of toxic substances.

Forever oral intake of glutathione was the limiting factor for its use in dietary supplements: the human intestine contains significant amounts of the enzyme gamma-glutamyltranspeptidase, responsible for the degradation of glutathione after oral ingestion. This molecule was therefore truly effective only when administered by injection. Thanks to the unique absorption of GLR Setria® Sublingual, a next-generation reduced glutathione supplement, it is possible to bypass the enzymatic steps responsible for the molecule's loss of efficacy, ensuring optimal bioavailability of glutathione to the body.

Why is the action of glutathione so important? Twenty-four hours a day, seven days a week, free radicals are busy attacking our bodies at the cellular level. Scientists have discovered that this constant attack impacts overall health and well-being, including the health of our tissues and their aging. It appears that combating the damage caused by free radicals can allow us to age more gracefully and live a healthier life. For this reason, it's important to ensure our bodies have optimal levels of glutathione, a molecule that effectively combats oxidative stress.

How can GLR Setria® Sublingual help your body fight free radicals? Eating, exercising, and even breathing can create free radicals. These molecules, once formed, attack the body at the cellular level, stealing electrons from other molecules and triggering a chain reaction. SetriBol provides the body with reduced glutathione, a molecule that binds to free radicals, neutralizing their action.

Why is glutathione called the “Master Antioxidant”? Glutathione doesn't just neutralize free radicals: it also has the ability to reactivate other antioxidant molecules, such as vitamins C and E. Normally, after antioxidants (such as vitamin C and vitamin E) have performed their job of inactivating free radicals, they themselves become unstable radicals. Glutathione helps recycle these molecules, restoring their function and extending their ability to attack free radicals. For this reason, glutathione is considered the "master" molecule or "king" of all antioxidants in the body.

How does GLR Setria® Sublingual help eliminate toxins? Glutathione supports the function of the liver, kidneys, gastrointestinal tract, and intestines, the body's main detoxification pathways. It works on two different fronts:

1. Helps eliminate toxins, ingested chemicals and potential carcinogens that the body has already absorbed;
2. It intercepts and neutralizes toxins in the gastrointestinal tract before they are absorbed.

Why can GLR Setria® Sublingual also be useful for athletes? Scientific research suggests that Setria® glutathione may support nitric oxide (NO) production when combined with L-Citrulline and used for endurance performance. **Setria® also appears to help maintain elevated NO levels, which may reduce fatigue and speed recovery. GLR Setria® Sublingual may therefore assist with strength training by maintaining increased post-workout nitric oxide production.