GLR Setria® Sublingual 30 chewable, orally disintegrating tablets by YAMAMOTO

Yamamoto® Research GLR® Setria® Sublingual is a dietary supplement in fast-dissolving sublingual tablets that provides 250 mg per daily dose ofreduced L-glutathione (Setria®)alongwithvitamin C and selenium. Glutathione is a powerful antioxidant molecule that plays a key role indefending the body against oxidative stressandthe action of free radicals, and is capable ofprotecting hepatocytes from toxic moleculesthatcould cause liver damage. The formulation infast-dissolving sublingual tabletsallowsthe body to rapidly and optimally absorb glutathione from the sublingual venous circulation draining into the superior vena cava, bypassing the intestinal activity of gamma-glutamyltransferases and avoiding enterocyte metabolic uptake. In this way, the “liver filter” is bypassed, and first-pass metabolism—which typically occurs in the liver and deactivates a significant portion of the glutathione molecule, rendering it less functional and effective—is avoided.

Glutathione is one of our first lines of defense; it is a ubiquitous molecule—meaning it is present throughout our entire body—but it isparticularly concentrated in the liver, where it protects liver cells from toxic molecules: in this case, glutathione “binds” to toxic metabolites, neutralizing them. Reduced glutathione is in fact capable of donating its hydrogen (H+), which acts as an electron (e-) acceptor from reactive oxygen species, i.e., free radicals. At this point, with the danger posed by free radicals eliminated, glutathione can regain its antioxidant activity and return to its reduced form. Glutathione’s ability to continuously regenerate is why this molecule is consideredthe most powerful antioxidant in the human body. Glutathione’s biologicalfunctionssupport its clinical utility in various situations, foremost among them its ability to protect the liver from the effects of toxic substances.

Oral intakeofglutathione has always been thelimiting factorinits use in dietary supplements: the human intestine contains significant amounts of the enzyme gamma-glutamyltranspeptidase, which is responsible for breaking down glutathione after oral ingestion. This molecule was therefore only truly effective when administered via injection. Thanks to the special absorption mechanism of GLR Setria® Sublingual, a new-generation reduced glutathione supplement, it is possible to bypass the enzymatic processes responsible for the molecule’s loss of efficacy, ensuring optimal bioavailability of glutathione for the body.

Why is glutathione so important?Twenty-fourhours a day, seven days a week, free radicals are constantly attacking our bodies at the cellular level. Scientists have discovered that this constant attack impacts overall health and well-being, including the health of our tissues and their aging process. It appears that combating the damage caused by free radicals can help us age better and live healthier lives: this is why it is important to ensure our bodies have optimal levels of glutathione, a molecule capable of effectively counteracting oxidative stress.

How can GLR Setria® Sublingual help your body fight free radicals?Eating, exercising, and even breathing are activities that can lead to the formation of free radicals. Once formed, these molecules attack the body at the cellular level, stealing electrons from other molecules and triggering a chain reaction. SetriBol supplies the body with reduced glutathione, a molecule that binds to free radicals, neutralizing their action.

Why is glutathione called the "Master Antioxidant" or the "King of Antioxidants"? Glutathione doesn’t just neutralize free radicals: it also has the ability to reactivate other antioxidant molecules, such as vitamins C and E. In fact, normally, after antioxidants (such as vitamins C and E) have done their job of inactivating free radicals, they themselves become unstable radicals. Glutathione helps recycle these molecules, restoring their function and extending their ability to attack free radicals: for this reason, glutathione is considered the “master” or “King” molecule of all the body’s antioxidants.

How does GLR Setria® Sublingual help eliminate toxins?Glutathionesupports the function of the liver, kidneys, gastrointestinal tract, and intestines—the body’s primary detoxification pathways. It works in two different ways:

1. It helps eliminate toxins, ingested chemicals, and potential carcinogens that the body has already absorbed;
2. It intercepts and neutralizes toxins in the gastrointestinal tract before they are absorbed.

Why might GLR Setria® Sublingual also be beneficial for athletes? Scientificresearchsuggests that Setria® glutathione may support nitric oxide (NO) production when combined with L-citrulline and used during endurance performance. **Setria® also appears to help maintain high levels of NO, which may reduce fatigue and speed up recovery. GLR Setria® Sublingual can therefore provide support for strength training by maintaining increased nitric oxide production post-workout.