Coletix 30 tablets YAMAMOTO

Coletix is the result of ongoing research by the Yamamoto® Research R&D team. It is a dietary supplement containingOlecol®-certified olive extract,fermented red rice(Monascus purpureus),andgamma-oryzanol,supplemented withcoenzyme Q10. Thanks to the synergy of its active ingredients, it supportshealthy blood circulationandhelps maintain normalblood pressure. Coletix provides 58 mg per daily dose of fermented red rice standardized to 2.76% total monacolins (2.76 mg per daily dose, in compliance with new European regulations on the use of Monacolin K).

Cardiovascular diseases are currently among the leading causes of disability and mortality in both Western and developing countries, and are exacerbated by unhealthy lifestyles, an unbalanced diet, excessive consumption of "junk food," little or no physical activity, and smoking. The main factors influencing susceptibility to cardiovascular diseases and disorders are cholesterol imbalance (hypercholesterolemia), hypertriglyceridemia, hypertension, diabetes, and insulin resistance, in addition to obesity. Specifically, it is importantto monitor the entire lipid profiletoprevent the formation of atherosclerotic plaques along the walls of blood vessels, which are promoted by inflammation and hypertension; these plaques pose a potential risk of obstructing the vessels and causing very serious consequences for the cardiovascular system.

Coletixisthe product developed by Yamamoto® Research topromote and support healthy blood circulation,heart health, andmaintainnormal blood triglyceride levels. The formulation features a titrated and standardized plant extract, which ensures that the natural active ingredients remain consistent in both quality and quantity, guaranteeing the product’s stability, bioavailability, and efficacy. The product offers the following synergies:

• Olecol® olive extract;

• Fermented red rice;

• Gamma-oryzanol;

• Coenzyme Q10.

Specifically,Monacolin Kfromfermented red riceisa molecule belonging to the Monacolin group, which is produced through the fermentation of common red rice (Oryza sativa) by the yeastMonascus purpureus—also known as“red yeast”—which gives it its characteristic color. Traditionally used in Asian cuisine as a substitute for vinegar and as a health-promoting agent, the fermentation of this rice yields numerous substances—the monacolins—which havecholesterol-lowering properties. Traditional Chinese Medicine, in fact, recommends the consumption of fermented red rice totreat circulatory disordersandalso in cases of gastrointestinal discomfort, but the discovery of the molecule to which most of its beneficial properties are attributed dates back to 1979. In that year, Professor Aika Endo, while studying the fermentation of “red yeast,” discovered that a metabolite produced during the fermentation process could inhibit the enzyme HMG-CoA reductase, one of the main enzymes involved in cholesterol synthesis (which occurs in the liver): this metabolite was Monacolin K.

Plant-based statins, such as Monacolin K, have been shown to havecholesterol-lowering properties. However, consumption must adhere to the recommended doses in accordance with current regulations to avoid side effects such as weakness, muscle pain, and gastrointestinal or liver problems.

Olive extractsupportsnormal blood circulationandhelps maintain healthy blood pressure. The oleuropein in Coletix is Olecol®, a patented Bioactor product that is highly water-soluble and standardized, extracted from olive leaves, with a very high concentration of bioavailable oleuropein. Thanks to a dual mechanism of action, it has been shown to support normal blood circulation and help maintain healthy blood pressure. It is a natural ingredient that offers a safe approach to managing blood lipid levels, capable of combating lipid oxidation, and whose efficacy has also been demonstrated by numerous randomized, placebo-controlled studies.

Gamma-oryzanolisa substance extracted from rice bran oil; it is also found in wheat bran, certain fruits, and certain vegetables.

Coenzyme Q10, also known as ubiquinone due to its ubiquitous role in the body, is a molecule of great importance to our body. It is found primarily in the mitochondria—the powerhouses of cells—and in the heart muscle, although it is present in many human tissues. It is involved in the cell’s electron transport processes and is apowerful antioxidantthatprotects membranes from oxidative damage. Since cholesterol-lowering statins also reduce the production of Coenzyme Q10, it is very beneficial to replenish levels of this substance when taking active ingredients—even natural ones—that could lower its physiological levels.